NSC 33994

• Description:

  NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

• UNSPSC:

  12352005

• Target:

  Autophagy; JAK

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nsc-33994.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC/C(C1=CC=C(O)C(CN(CC)CC)=C1)=C(C2=CC=C(O)C(CN(CC)CC)=C2)/CC

• Molecular Formula:

  C28H42N2O2

• Molecular Weight:

  438.65

• References & Citations:

  [1]Róbert Kiss, et al. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3598-601.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK2

• CAS Number:

  [82058-16-0]