NSC 33994

• Description :

  NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; JAK

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nsc-33994.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC/C(C1=CC=C(O)C(CN(CC)CC)=C1)=C(C2=CC=C(O)C(CN(CC)CC)=C2)/CC

• Molecular Formula :

  C28H42N2O2

• Molecular Weight :

  438.65

• References & Citations :

  [1]Róbert Kiss, et al. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3598-601.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  JAK2

• CAS Number :

  [82058-16-0]