Leupeptin

• UNSPSC Description:

  Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

• Target Antigen:

  Cathepsin; Ser/Thr Protease; Virus Protease

• Type:

  Peptides

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/leupeptin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N

• Molecular Weight:

  426.55

• References & Citations:

  [1]Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12(5):e0222021.|[2]Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42.|[3]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.|[4]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.Biochem Pharmacol. 2024 Dec 19:116720.|Biochim Biophys Acta Mol Cell Res. 2023 Jan 24;1870(3):119433.|Carbohydr Polym. 2023 Jun 9, 121108.|Chem Asian J. 2024 Sep 2:e202400824.|Emerg Microbes Infect. 2023 Apr 26;2207688.|Int J Biol Macromol. 2023 Jul 3;125670.|Nature. 2023 Jun;618(7966):799-807.|Redox Biol. 2024 Apr:70:103064.|Redox Biol. 2024 Mar 8, 103100.|Antiviral Res. 2020 Oct;182:104922.|Autophagy. 2021 Aug;17(8):1873-1888.|Autophagy. 2021 Jul;17(7):1592-1613.|Autophagy. 2024 Aug 30.|Autophagy. 2024 Jun 19.|Biochem Pharmacol. 2022: 115339.|bioRxiv. 2020 Jun.|bioRxiv. 2023 Nov 5.|bioRxiv. 2024 November 14.|Br J Pharmacol. 2023 Feb 14.|Cancer Lett. 2022 Mar 9;215629.|Cell Death Differ. 2022 Aug 22.|Cell Death Dis. 2022 Oct 12;13(10):865.|Cell Rep. 2021 Nov 2;37(5):109931.|Environ Toxicol. 2023 Nov 23.|Int J Oncol. 2019 Jul;55(1):331-339.|J Biol Chem. 2021, 100616.|J Clin Invest. 2022 Mar 1;132(5):e152170.|J Hematol Oncol. 2024 Sep 2;17(1):78.|mBio. 2024 Jun 28:e0053224.|Mol Biomed. 2023 Nov 17;4(1):42.|Natl Sci Rev. 2021 Feb 10;8(7):nwab024.|Nature. 2024 Aug;632(8025):686-694.|Nature. 2024 Aug;632(8026):930-937.|Neuro Oncol. 2022 Jun 21;noac157.|Oncol Rep. 2021 Dec;46(6):253.|Pharmacol Res. 2024 Jun 28:107252.|Sci Adv. 2021 Jan 1;7(1):eabe1340.|Sci Rep. 2022 Jul 16;12(1):12197.|Toxicol Appl Pharmacol. 2023 May 26;116568.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  55123-66-5