Lisinopril-d5

• Description :

  Lisinopril-d5 is the deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

• Product Name Alternative :

  MK-521-d5

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335, H361

• Target :

  Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Cardiovascular Disease

• Purity :

  96.0

• Solubility :

  H2O : 50 mg/mL (ultrasonic; warming)

• Smiles :

  [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CC[C@@H](C(O)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O

• Molecular Formula :

  C21H26D5N3O5

• Molecular Weight :

  410.52

• Precautions :

  H315, H319, H335, H361

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581 (18) : p. 3449-54.|[3]Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41 (3) : p. 207-24.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1356905-39-9]