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Lisinopril-d5

CAT: 0804-HY-18206SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18206SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lisinopril-d5 is the deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
CAS Number
1356905-39-9
Product Name Alternative
MK-521-d5
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H361
Target
Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Purity
96.0
Solubility
H2O : 50 mg/mL (ultrasonic; warming)
Smiles
[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CC[C@@H](C(O)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O
Molecular Formula
C21H26D5N3O5
Molecular Weight
410.52
Precautions
H315, H319, H335, H361
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581 (18) : p. 3449-54.|[3]Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41 (3) : p. 207-24.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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