TASP0277308

CAT: 0804-HY-18164-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-18164-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TASP0277308 is a highly selective S1P1 antagonist. TASP0277308 possesses immunomodulatory activities, including lymphopenia, a block in T cell egress from the thymus, marginal zone B cell displacement, and the upregulation of CD69 expression on lymphocytes. TASP0277308 can be used for the research of collagen-induced arthritis in mice[1].

CAS Number

945725-50-8

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tasp0277308.html

Purity

99.00

Solubility

10 mM in DMSO

Smiles

CCN1C(OC2=CC(N3CCN(CC3)C)=CC=C2)=NN=C1[C@@H](C)NS(=O)(C4=CC(Cl)=C(C=C4)Cl)=O

Molecular Formula

C23H28Cl2N6O3S

Molecular Weight

539.48

References & Citations

[1]Fujii Y, et al. Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J Immunol. 2012 Jan 1;188 (1) :206-15.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

TASP0277308

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