Fosnetupitant

• Description :

  Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].

• CAS Number :

  [1703748-89-3]

• Product Name Alternative :

  Pronetupitant

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  Neurokinin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fosnetupitant.html

• Purity :

  95.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=P(OC[N+]1(C)CCN(C2=NC=C(N(C)C(C(C)(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)=O)C(C4=CC=CC=C4C)=C2)CC1)([O-])O

• Molecular Formula :

  C31H35F6N4O5P

• Molecular Weight :

  688.60

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched