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Fosnetupitant

CAT: 0804-HY-17615Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17615Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].
CAS Number
1703748-89-3
Product Name Alternative
Pronetupitant
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/fosnetupitant.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=P(OC[N+]1(C)CCN(C2=NC=C(N(C)C(C(C)(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)=O)C(C4=CC=CC=C4C)=C2)CC1)([O-])O
Molecular Formula
C31H35F6N4O5P
Molecular Weight
688.60
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

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