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Rosuvastatin-d3

CAT: 0804-HY-17504ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17504ASSize:1 mg
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Description
Rosuvastatin-d3 (ZD 4522-d3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].
CAS Number
1133429-16-9
Product Name Alternative
ZD 4522 D3
UNSPSC
12352005
Target
Autophagy; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1C2=NC(N(C([2H])([2H])[2H])S(=O)(C)=O)=NC(C(C)C)=C2/C=C/[C@@H](O)C[C@@H](O)CC(O)=O
Molecular Formula
C22H25D3FN3O6S
Molecular Weight
484.56
References & Citations
[1]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5 (2) : p. 437-44.|[2]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62 (14) : p. 2075-85; discussion 2086-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

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RM-R192388-01Rosuvastatin D3
MBS5767519Rosuvastatin D3 sodium
CS-O-47475Rosuvastatin D3 Intermediate
CS-O-03030Rosuvastatin-d3 Sodium
TMIH-0505-01Rosuvastatin-d3 intermediate
CS-B-00367Rosuvastatin-d3 Calcium Salt
458822-01N-Desmethyl Rosuvastatin-d3
CS-O-47215Rosuvastatin D3 sodium (Mixture)
TRC-R700501-10MGRosuvastatin-d3 Sodium Salt
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