(1S,2R)-Tranylcypromine (hydrochloride)

(1S,2R)-Tranylcypromine (hydrochloride)

• CAS Number: 4548-34-9
• UNSPSC Description: (1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent. (1S,2R)-Tranylcypromine hydrochloride can inhibits MAO and LSD1[1][2].
• Target Antigen: Histone Demethylase; Monoamine Oxidase
• Type: Reference compound
• Related Pathways: Epigenetics;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/1s-2r-tranylcypromine-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@H]1C[C@@H]1C2=CC=CC=C2.[H]Cl
• Molecular Weight: 169.65
• References & Citations: [1]TetsuyaEzawa, et al. Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine. Tetrahedron: Asymmetry. 15 December 2017;28(12):1690-1699.|[2]Valente S, et al. Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. ACS Med Chem Lett. 2014 Dec 8;6(2):173-7.
• Shipping Conditions: Room temperature
• Clinical Information: Launched