Bepridil

• Description:

  Bepridil ((±) -Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].

• Product Name Alternative:

  (±) -Bepridil; Org 5730

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Calcium Channel; SARS-CoV; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/bepridil.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC (COCC (CN (C1=CC=CC=C1) CC2=CC=CC=C2) N3CCCC3) C

• Molecular Formula:

  C24H34N2O

• Molecular Weight:

  366.54

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Yatani A, et al. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237 (1) :9-17.|[2]Vatansever EC, et al. Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci U S A. 2021 Mar 9;118 (10) :e2012201118.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  64706-54-3