Bepridil

• UNSPSC Description:

  Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].

• Target Antigen:

  Calcium Channel; SARS-CoV; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/bepridil.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(COCC(CN(C1=CC=CC=C1)CC2=CC=CC=C2)N3CCCC3)C

• Molecular Weight:

  366.54

• References & Citations:

  [1]Yatani A, et al. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17.|[2]Vatansever EC, et al. Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2012201118.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  64706-54-3