Tesetaxel

CAT: 0804-HY-16491Size: 1 EachDry Ice: NoHazardous: No

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Description

Tesetaxel is a orally active, semisynthetic microtubule inhibitor of the taxane class for the research of cancer, including colorectal and gastric cancer.

CAS Number

333754-36-2

Product Name Alternative

DJ-927

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tesetaxel.html

Solubility

10 mM in DMSO

Smiles

CC(O[C@]12[C@]3([H])[C@]([C@@]4([H])[C@@](O[C@H](O4)CN(C)C)([H])C5=C(C)[C@@H](OC([C@H](O)[C@H](C6=C(C=CC=N6)F)NC(OC(C)(C)C)=O)=O)C[C@@](O)([C@H]3OC(C7=CC=CC=C7)=O)C5(C)C)(CC[C@@]1([H])OC2)C)=O

Molecular Formula

C46H60FN3O13

Molecular Weight

881.98

References & Citations

[1]Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci. 2003;94 (5) :459-466. |[2]Saif MW, Sarantopoulos J, Patnaik A, Tolcher AW, Takimoto C, Beeram M. Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2011;68 (6) :1565-1573.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Tesetaxel

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