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Zalypsis

CAT: 0804-HY-16401Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16401Size:1 Each
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Description
Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks[1][2].
CAS Number
308359-57-1
Product Name Alternative
PM00104
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zalypsis.html
Solubility
10 mM in DMSO
Smiles
O=C(NC[C@H]1C2=C3C(OCO3)=C(C)C(OC(C)=O)=C2C[C@]4([H])N1[C@@H](O)[C@@]5([H])N(C)[C@]4([H])C6=C(C5)C=C(C)C(OC)=C6O)/C=C/C7=CC(C(F)(F)F)=CC=C7
Molecular Formula
C37H38F3N3O8
Molecular Weight
709.71
References & Citations
[1]Duan Z, et al. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May;63 (6) :1121-9.|[2]Petek BJ, et al. PM00104 (Zalypsis®) : a marine derived alkylating agent. Molecules. 2014 Aug 15;19 (8) :12328-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
T29202-01Zalypsis

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