RegisterLogin
Hot

Pladienolide B

CAT: 0804-HY-16399-01Size: 100 µgDry Ice: NoHazardous: No
CAT#:0804-HY-16399-01Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis[1][2][3].
CAS Number
[445493-23-2]
UNSPSC
12352005
Target
Apoptosis; SF3B1
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pladienolide-b.html
Purity
99.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)C1
Molecular Formula
C30H48O8
Molecular Weight
536.70
References & Citations
[1]Effenberger KA, et al. Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs. J Biol Chem. 2014 Jan 24;289 (4) :1938-47.|[2]Aouida M, et al. CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B. Biochim Open. 2016 Feb 24;3:72-75.|[3]Zhang Q, et al. Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells. Artif Cells Nanomed Biotechnol. 2019 Dec;47 (1) :1273-1280.|[4]Mizui Y, et al. Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities. J Antibiot (Tokyo) . 2004 Mar;57 (3) :188-96.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N12655Pladienolide A
HY-N11436-01Aconicarchamine B
HY-N7688-01Regaloside B
HY-N7552-01Isodaphnoretin B
HY-N3576-01Henriol B
HY-N4184-01Licoflavone B
HY-N8167-01Plantanone B
HY-D0259-01Erythrosine B
HY-N2365-01Macamide B
HY-123898-01Cepharadione B

Alternative Products

CatalogName
MBS385645-01Pladienolide B
TN7766-01Pladienolide A
A12699-0.1Pladienolide B 100ug
A12699-0.5Pladienolide B 500ug
A12699-1Pladienolide B 1mg
A12699-2Pladienolide B 2mg
6070/500UPladienolide B 500 µg

Popular Products