PARP7-IN-18

• UNSPSC Description:

  Parp7-in-18 (Compund 8) is a selective PARP7 inhibitor with an IC50 of 0.11 nM. PARP7-IN-18 exhibits good anticancer activity and pharmacokinetic properties[1].

• Target Antigen:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/parp7-in-18.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NN=CC(N2CC[C@H]2COCCC(N3C[C@H]4N(C5=C(OCC4)C=C(Cl)C=N5)CC3)=O)=C1C(F)(F)F

• Molecular Weight:

  542.94

• References & Citations:

  [1]Xu J, et al. Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability[J]. European Journal of Medicinal Chemistry, 2024: 116160.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2819999-00-1