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PARP7-IN-18

CAT: 0804-HY-162172Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162172Size:1 Each
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Description
Parp7-in-18 (Compund 8) is a selective PARP7 inhibitor with an IC50 of 0.11 nM. PARP7-IN-18 exhibits good anticancer activity and pharmacokinetic properties[1].
CAS Number
2819999-00-1
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp7-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C1NN=CC(N2CC[C@H]2COCCC(N3C[C@H]4N(C5=C(OCC4)C=C(Cl)C=N5)CC3)=O)=C1C(F)(F)F
Molecular Formula
C23H26ClF3N6O4
Molecular Weight
542.94
References & Citations
[1]Xu J, et al. Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability[J]. European Journal of Medicinal Chemistry, 2024: 116160.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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