MR-2088

• Description :

  MR-2088 is a selective ULK1/ULK2 inhibitor with pEC50 values of 8.3 and 8.7, respectively. MR-2088 selectively inhibits autophagy through ULK1/2 mediated inhibition[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; ULK

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mr-2088.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCC(F)(F)F)C1=CC(C2=CN=C3C(C=C(C4=CCCNC4)N3)=C2)=CS1

• Molecular Formula :

  C19H17F3N4OS

• Molecular Weight :

  406.42

• References & Citations :

  [1]Alisa Morozova, et al. Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties. European Journal of Medicinal Chemistry. 29 December 2023, 116101.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ULK1; ULK2

• CAS Number :

  [2922531-69-7]