TP0628103

• UNSPSC Description:

  TP0628103 (compound 18) is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis[1].

• Target Antigen:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/tp0628103.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)([C@@H](C(NC1=CC=C(C(N2CCC(C(N[C@@H](C(N3CC[C@@H](C3)N)=O)CCCCN)=O)CC2)=O)C=C1)=O)NC([C@@H](NC(CNC(CC[C@@H](C(O)=O)NS(=O)(C4=CC(C(F)(F)F)=C(Cl)C=C4)=O)=O)=O)CC5=CC=NC=C5)=O)C

• Molecular Weight:

  1134.66

• References & Citations:

  [1]Yusuke Oka, et al. Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c01967.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2865102-08-3