HKI12134085

CAT: 0804-HY-161065Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-161065Size:1 Each

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Description

HKI12134085 (compound 3) is an orally available antibacterial nitrobenzothiazinone (BTZ) derivative with activity against Mycobacterium tuberculosis. HKI12134085 has in vivo inhibitory potency in a BALB/c mouse model of Mycobacterium tuberculosis infection[1].

CAS Number

2102393-11-1

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hki12134085.html

Solubility

10 mM in DMSO

Smiles

[O-][N+](C1=C(SC(N2CCC3(OC[C@H](C)O3)CC2)=NC4=O)C4=C(C)C(C(F)(F)F)=C1)=O

Molecular Formula

C18H18F3N3O5S

Molecular Weight

445.41

References & Citations

[1]Joch M, et al. Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones. Eur J Med Chem. 2024 Jan 15;264:116023.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19235250-01	HKI12134085

HKI12134085

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