TP1L

CAT: 0804-HY-160151Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-160151Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC50 value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: , Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002) ).

UNSPSC

12352005

Target

IFNAR; JAK; MHC; Phosphatase; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tp1l.html

Solubility

10 mM in DMSO

Smiles

FC(C1=CC=C(C[C@H](NC([C@@H](NC(CO[C@@H]2[C@@H](C(C)C)CC[C@H](C)C2)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CCCCNC(C4=CC=C(CC)C=C4)=O)C(NCCOCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)=O)=O)C=C1)(P(O)(O)=O)F

Molecular Formula

C64H81F2N8O14P

Molecular Weight

1255.34

References & Citations

[1]Miao J, et al. Discovery of a selective TC-PTP degrader for cancer immunotherapy. Chem Sci. 2023 Oct 24;14 (44) :12606-12614.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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