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Flupentixol

CAT: 0804-HY-15856ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15856ASize:1 Each
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Description
Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM) . Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].
CAS Number
2709-56-0
Product Name Alternative
Flupenthixol
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Apoptosis; Dopamine Receptor; PI3K
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/flupentixol.html
Solubility
10 mM in DMSO
Smiles
OCCN1CCN(CC/C=C2C3=C(SC4=C/2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1
Molecular Formula
C23H25F3N2OS
Molecular Weight
434.52
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Yonar D, et al. Effect of cis- (Z) -flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.|[2]Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31 (5) :1012-22.|[3]Chao Dong, et al. The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer. Int J Biol Sci. 2019 Jun 2;15 (7) :1523-1532.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D1 Receptor; D2 Receptor; PI3Kα

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