FR173657

CAT: 0804-HY-15791Size: 1 EachDry Ice: NoHazardous: No

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Description

FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively) . FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg) . FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg) . FR173657 can be used for research of inflammatory disease[1].

CAS Number

167838-64-4

Product Name Alternative

FK-3657

UNSPSC

12352005

Target

Bradykinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fr173657.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC(N(C1=CC=C(Cl)C(COC2=C3N=C(C)C=CC3=CC=C2)=C1Cl)C)=O)/C=C/C4=CC=C(NC(C)=O)N=C4

Molecular Formula

C30H27Cl2N5O4

Molecular Weight

592.47

References & Citations

[1]Asano M, et al. The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657. Br J Pharmacol. 1997 Feb;120 (4) :617-24.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

FR173657

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