NCI-14465

• Description:

  NCI-14465 is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) inhibitor with an IC 50 of 26.4 μM. NCI-14465 can be used in cancer research[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nci-14465.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(NC2=CC=C3C=CC=CC3=C2)=NC(NC4=CC=C(C)C=C4)=N1.Cl

• Molecular Formula:

  C20H19ClN6

• Molecular Weight:

  378.86

• References & Citations:

  [1]Rohilla A, et al. Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP. Microbiol Spectr. 2024 Jan 11;12 (1) :e0201223.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1144534-31-5]