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MEDS433

CAT: 0804-HY-156442-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156442-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication[1].
CAS Number
2241027-61-0
UNSPSC
12352005
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/meds433.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=CN2N=C1O)NC3=C(F)C(F)=C(C4=CC=CC=C4)C(F)=C3F
Molecular Formula
C20H11F4N3O2
Molecular Weight
401.31
References & Citations
[1]Anna Luganini, et al. Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication. Antiviral Res. 2023 Oct 16:219:105734.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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