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AuM1Phe

CAT: 0804-HY-156403Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156403Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 1.2 μM[1].
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aum1phe.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=CC=C1)CN(C2[Au]OC([C@H](CC3=CC=CC=C3)NC(OC(C)(C)C)=O)=O)C(Cl)=C(N2C)Cl
Molecular Formula
C26H30AuCl2N3O5
Molecular Weight
732.40
References & Citations
[1]Domenico Iacopetta, et al. NHC-Ag (I) and NHC-Au (I) Complexes with N-Boc-Protected α-Amino Acidate Counterions Powerfully Affect the Growth of MDA-MB-231 Cells. ACS Med. Chem. Lett. 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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