Products for Research Use Only
RegisterLogin

PSEN1-IN-2

CAT: 0804-HY-156012Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-156012Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PSEN1-IN-2 (Compound 13K) is a PSEN1 inhibitor. PSEN1-IN-2 inhibits PSEN1-APH1A and PSEN1-APH1B complex with IC50s of 6.9 and 2.4 nM. PSEN1-IN-2 can be used for Alzheimer's disease research[1].
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/psen1-in-2.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C[C@@H]2CC[C@H]1[C@H](N2S(C3=CC=C(Cl)C=C3)(=O)=O)C4=CC=C(C#N)C=C4F
Molecular Formula
C20H18ClFN2O3S
Molecular Weight
420.88
References & Citations
[1]Narlawar R, et al. Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors. Eur J Med Chem. 2023 Nov 15;260:115725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-156011PSEN1-IN-1
HY-178128PSEN1-IN-3
HY-RS11276PSEN1 Human Pre-designed siRNA Set A
HY-RS18076Psen1 Mouse Pre-designed siRNA Set A
HY-RS24551Psen1 Rat Pre-designed siRNA Set A
HY-W011060-01Cryptand 2.2.2
HY-B1500-012,2,2-Trichloroethanol
HY-W0733142,2,2-Trifluoroethoxyamine (hydrochloride)
HY-N2048-012,2':5',2''-Terthiophene
HY-132268-01Cav 2.2 blocker 2

Alternative Products

CatalogName
GTR19230356-01PSEN1-IN-2
527342-01PSEN1
T79679-01PSEN1-IN-1
70R-21658PSEN1 antibody
573591-01PSEN1 (HRP)

Popular Products