VEGFR/PARP-IN-1

VEGFR/PARP-IN-1

• CAS Number: 3010256-54-6
• UNSPSC Description: VEGFR/PARP-IN-1 (Compound 14b) is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively). VEGFR/PARP-IN-1 inhibits DNA damage repair, induces cell apoptosis, and arrests cell in the G2/M phase. VEGFR/PARP-IN-1 has good antiproliferative efficacy against BRCA wild-type breast cancer cells (IC50: 4.1 and 3.5 μM for MDA-MB-231 and MCF-7 cells). VEGFR/PARP-IN-1 is an antitumor and anti-metastasis agent[1].
• Target Antigen: Apoptosis; PARP; VEGFR
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr-parp-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC(C1=CC=CC2=C1N=C(N2)C3=C(C=CC(NC4=NC=CC(N(C)C5=CC6=NN(C(C)=C6C=C5)C)=N4)=C3)C)=O
• Molecular Weight: 517.58
• References & Citations: [1]Li Y, et al. Discovery, Synthesis, and Evaluation of Novel Dual Inhibitors of a Vascular Endothelial Growth Factor Receptor and Poly(ADP-Ribose) Polymerase for BRCA Wild-Type Breast Cancer Therapy. J Med Chem. 2023 Aug 24.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported