UNC7096

CAT: 0804-HY-155817Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155817Size:1 Each
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Description
UNC7096 (compound 53) is a biotinylated affinity reagent. The phenyl ring of UNC7096 replaces the pyrimidine ring in UNC6934 (HY-145103) and introduces biotin at the para position of the phenyl ring, which has a high binding affinity to the NSD2-PWWP1 domain (Kd=46 nM) . UNC7096 blocks the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 by occupying the methyl-lysine binding pocket of NSD2-PWWP1. This binding is achieved by covalent binding through the formation of hydrogen bonds and a specific aromatic cage structure. UNC7096 can be used to capture proteins that interact with the NSD2-PWWP1 domain to further analyze the biological significance of these interactions[1].
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/unc7096.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CC1=CC=C(C(NC2=CC=C(C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]3[C@](NC(N4)=O)([H])[C@]4([H])CS3)=O)=O)C=C2)=O)C=C1)C5CC5)C6=CC(OCC(N7)=O)=C7C=C6
Molecular Formula
C61H87N7O18S
Molecular Weight
1238.44
References & Citations
[1]Zonghui Ma, et al. Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2. J Med Chem. 2023 Aug 24;66 (16) :10991-11026
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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