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SHR5428

CAT: 0804-HY-155787Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155787Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHR5428 is a potent, orally active, selective and noncovalent inhibitor of CDK7 with highly potent CDK7 enzymatic activity (IC50=2.3 nM) . SHR5428 inhibits triple negative breast cancer cellular activity on MDA-MB-468 cell (IC50=6.6 nM) [1].
CAS Number
3054791-71-5
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shr5428.html
Solubility
10 mM in DMSO
Smiles
CP(C1=C(C=CC2=C1NC=C2C3=C(C=NC(N[C@@H]4C[C@H](CCC4)O)=N3)C(F)(F)F)C#N)(C)=O
Molecular Formula
C22H23F3N5O2P
Molecular Weight
477.42
References & Citations
[1]Jia M, et al. Discovery of SHR5428 as a selective and noncovalent inhibitor of CDK7. Bioorg Med Chem Lett. 2023 Sep 1;93:129429.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK12; CDK2; CDK4; CDK6; CDK7; CDK9

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