fac-[Re(CO)3(L3)(H2O)][NO3]

fac-[Re(CO)3(L3)(H2O)][NO3]

• UNSPSC Description: fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy[1].
• Target Antigen: Paraptosis
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/fac-re-co-3-l3-h2o-no3.html
• Solubility: 10 mM in DMSO
• Smiles: [OH2][Re+]1([N]2=CC=CC3=C2C4=C(C5=C3N=C(C6=CNC7=C6C=C(OC)C=C7)N5)C=CC=[N]41)([C]=O)([C]=O)[C]=O.[O-][N+]([O-])=O
• Molecular Weight: 715.64
• References & Citations: [1]Enslin LE, et al. Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity. Inorg Chem. 2023 Aug 7;62(31):12237-12251.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported