NDBM

CAT: 0804-HY-155717Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-155717Size:1 Each

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Description

NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation[1].

CAS Number

2958641-42-2

UNSPSC

12352005

Target

Autophagy; Pim

Type

Reference compound

Related Pathways

Autophagy; JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ndbm.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C2OC(C(NCCOCCOCCN3C(C4=C5C(C(NCCN6CCOCC6)=CC=C5C3=O)=CC=C4)=O)=O)=CC2=C1

Molecular Formula

C33H35BrN4O7

Molecular Weight

679.56

References & Citations

[1]Liu C, et al. Multifunctional Theranostic Probe Based on the Pim-1 Kinase Inhibitor with the Function of Tracking pH Fluctuations during Treatment. Anal Chem. 2023;95 (31) :11732-11740.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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