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J27644

CAT: 0804-HY-155699-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155699-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
J27644 is a potent HDAC inhibitor. J27644 mitigates TGF-β-induced pulmonary fibrosis[1].
CAS Number
3033032-03-7
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/j27644.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=O)C2=CC=CC(Cl)=C2N1CC3=CC=C(C=C3)C(NO)=O
Molecular Formula
C16H12ClN3O4
Molecular Weight
345.74
References & Citations
[1]Yu WC, et, al. Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis. J Med Chem. 2023 Aug 10;66 (15) :10528-10557.|[2]Yu WC, et, al. Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis. J Med Chem. 2023 Aug 10;66 (15) :10528-10557.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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