KSK94

• Description:

  KSK94 is a high-affinity histamine H3 receptor antagonist, with Kis of 7.9, 2958, 75.2 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK94 can be used for research of nociceptive and neuropathic pain[1].

• UNSPSC:

  12352005

• Target:

  Histamine Receptor; Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ksk94.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC(C=C1)=CC=C1C2=CC=C(OCCCN3CCN(C4=CC=NC=C4)CC3)C=C2

• Molecular Formula:

  C25H26N4O

• Molecular Weight:

  398.50

• References & Citations:

  [1]Szczepańska K, et al. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 27;66 (14) :9658-9683.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2566716-07-0]