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10m/ZS44

CAT: 0804-HY-155532Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155532Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells[1].
CAS Number
3008988-49-3
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/10m-zs44.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C(/C=C/C2=CC=C(C=C2)C(N3CCN(C34COC4)CC5=CC=CC=C5)=O)=O)=CC(OC)=C1OC
Molecular Formula
C31H32N2O6
Molecular Weight
528.60
References & Citations
[1]Zhu H, et al. Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents. Eur J Med Chem. 2023 Oct 5;258:115595.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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