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HYDAMTIQ

CAT: 0804-HY-155458Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155458Size:1 Each
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Description
HYDAMTIQ is a PARP-1/2 inhibitor (IC50: 29-38 nM) with anticancer, anti-inflammatory, and ischemic protective effects. HYDAMTIQ inhibits pulmonary PARP activity, is effective against allergen-induced cough and dyspnea, and inhibits bronchial hyperresponsiveness to methacholine. HYDAMTIQ has broad-spectrum tumor suppressor effects, including ovarian and breast cancers, prostate and pancreatic tumors, and glioblastoma multiforme. HYDAMTIQ has demonstrated in vivo efficacy in animal models of cerebral ischemia, asthma, cancer, and more[1].
CAS Number
1201832-32-7
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hydamtiq.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(CN(C)C)S2)C3=C(O)C=CC=C31
Molecular Formula
C14H14N2O2S
Molecular Weight
274.34
References & Citations
[1]Filipponi P et al. Continuous Flow Synthesis of the PARP-1/2 Inhibitor HYDAMTIQ: Synthetic Strategy, Optimization, and Green Metrics Evaluation[J]. Organic Process Research & Development, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19235129-01HYDAMTIQ

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