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Mz325

CAT: 0804-HY-155392Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155392Size:1 Each
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Description
Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration[1].
CAS Number
3032670-12-2
UNSPSC
12352005
Target
HDAC; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mz325.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC=C(S1)CC2=CC=CC(OCC3=CN(N=N3)CCCCC(N(CC4=CC=C(C=C4)C(NO)=O)CCCC)=O)=C2)CSC5=NC(C)=CC(C)=N5
Molecular Formula
C38H45N9O5S2
Molecular Weight
771.95
References & Citations
[1]Laura Sinatra, et al. Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J Med Chem. 2023 Nov 9;66 (21) :14787-14814.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
MBS5823377Mz325

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