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FD2056

CAT: 0804-HY-155180Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155180Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FD2056 is a potent and orally active PI3K inhibitor. FD2056 inhibits PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ with IC50s of 0.30, 0.80, 1.10, 0.42 nM. FD2056 also inhibits CDK2-CyclinA2 and CDK4-CyclinD3 with IC50 of 115.95 and 2782.15 nM. FD2056 inhibits breast cancer cell proliferation with IC50s of 1.06, 0.04, 1.40 μM for MDA-MB-231, MDA-MB-468, MCF-7 cells. FD2056 also induces cancer apoptosis and inhibits tumor growth[1].
CAS Number
2685870-87-3
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fd2056.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC=C1)(NC2=CC(C3=CN=C(NC=C4C5=CC(N)=NC=C5)C4=C3)=CN=C2Cl)=O
Molecular Formula
C23H17ClN6O2S
Molecular Weight
476.94
References & Citations
[1]Yang C, et al. Discovery and identification of a novel PI3K inhibitor with enhanced CDK2 inhibition for the treatment of triple negative breast cancer. Bioorg Chem. 2023 Aug 9;140:106779.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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