CHBO4

CAT: 0804-HY-155137-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-155137-01Size:1 mg

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Description

CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS) . CHBO4 can be used for Parkinson's Disease (PD) research[1].

CAS Number

98991-32-3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Monoamine Oxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chbo4.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C(C(/C=C/C2=CC=C(F)C=C2)=O)C=C1

Molecular Formula

C15H10BrFO

Molecular Weight

305.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Thomas Parambi DG, et al. Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study. Comput Biol Chem. 2023 Aug;105:107899.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAO-B

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