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SRE-II

CAT: 0804-HY-155070Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155070Size:1 Each
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Description
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sre-ii.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C1)C2=CC=CC3=C(NC(CCl)=O)C(I)=CC1=C32
Molecular Formula
C15H9ClINO2
Molecular Weight
397.59
References & Citations
[1]Qiaoyun Jiang, et al. Lysosome-targeting phenalenones as efficient type I/II photosensitizers for anticancer photodynamic therapy. Eur J Med Chem. 2023 Jul 5;255:115418.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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