SRE-II

SRE-II

• UNSPSC Description: SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer[1].
• Target Antigen: Apoptosis; DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sre-ii.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C=C1)C2=CC=CC3=C(NC(CCl)=O)C(I)=CC1=C32
• Molecular Weight: 397.59
• References & Citations: [1]Qiaoyun Jiang, et al. Lysosome-targeting phenalenones as efficient type I/II photosensitizers for anticancer photodynamic therapy. Eur J Med Chem. 2023 Jul 5;255:115418.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported