MCI

• Description :

  MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) [1].

• UNSPSC :

  12352005

• Target :

  COX; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mci.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1[C@H](O)[C@H](CO)OC(OCCN2C=C(C[C@H](NC(/C=C/C3=CC(O)=C(O)C=C3)=O)C(NCCCCNC(CC4=C(C)N(C(C5=CC=C(Cl)C=C5)=O)C6=CC=C(OC)C=C46)=O)=O)N=N2)[C@H]1O

• Molecular Formula :

  C45H52ClN7O13

• Molecular Weight :

  934.39

• References & Citations :

  [1]Luo X, et al. Macrophage Reprogramming via Targeted ROS Scavenging and COX-2 Downregulation for Alleviating Inflammation. Bioconjug Chem. 2023 Jul 19;34 (7) :1316-1326.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  COX-2