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MCI

CAT: 0804-HY-155031Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155031Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) [1].
UNSPSC
12352005
Target
COX; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/mci.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](O)[C@H](CO)OC(OCCN2C=C(C[C@H](NC(/C=C/C3=CC(O)=C(O)C=C3)=O)C(NCCCCNC(CC4=C(C)N(C(C5=CC=C(Cl)C=C5)=O)C6=CC=C(OC)C=C46)=O)=O)N=N2)[C@H]1O
Molecular Formula
C45H52ClN7O13
Molecular Weight
934.39
References & Citations
[1]Luo X, et al. Macrophage Reprogramming via Targeted ROS Scavenging and COX-2 Downregulation for Alleviating Inflammation. Bioconjug Chem. 2023 Jul 19;34 (7) :1316-1326.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
COX-2

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