N-4′-(p-Trifluoromethylphenyl)butyl-DAB

CAT:

804-HY-154995

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CAS Number: 3033570-20-3
UNSPSC Description: N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) is an agonit of lysosomal acid α-glucosidase (GAA). N-4′-(p-Trifluoromethylphenyl)butyl-DAB increases intracellular GAA activities dose-dependently, in Pompe patient's fibroblasts with the M519V mutation[1].
Target Antigen: Glycosidase
Type: Reference compound
Related Pathways: Metabolic Enzyme/Protease
Applications: COVID-19-immunoregulation
Field of Research: Infection
Assay Protocol: https://www.medchemexpress.com/n-4-p-trifluoromethylphenyl-butyl-dab.html
Solubility: 10 mM in DMSO
Smiles: O[C@@H]1[C@@H](CO)N(CCCCC2=CC=C(C(F)(F)F)C=C2)C[C@H]1O
Molecular Weight: 333.35
References & Citations: [1]Kato A, et al. Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase. J Med Chem. 2023 Jul 13;66(13):9023-9039.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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