2'-F-2'-ara-N2-ibu-dG Phosphoramidite

2'-F-2'-ara-N2-ibu-dG Phosphoramidite

• CAS Number: 1404463-20-2
• UNSPSC Description: 2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/2-f-2-ara-n2-ibu-dg-phosphoramidite.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC(NC(C(C)C)=O)=NC2=C1N=CN2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)[C@@H](OP(OCCC#N)C(C(C)C)C(C)C)[C@@H]3F
• Molecular Weight: 856.92
• References & Citations: [1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported