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FdUMP (triethylammonium)

CAT: 0804-HY-154508-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-154508-01Size:1 mg
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Description
FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU) . 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
CAS Number
134-46-3
Product Name Alternative
2’-Deoxy-5-Fluorouridine 5’-phosphate (triethylammonium)
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog; Thymidylate Synthase
Type
Oligonucleotides
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-deoxy-5-fluorouridine-5-phosphate-triethylammonium.html
Purity
99.96
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
Molecular Formula
C21H42FN4O8P
Molecular Weight
528.55
References & Citations
[1]Ghoshal K, Jacob ST. An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997;53 (11) :1569-1575.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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