5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite

5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite

• CAS Number: 152753-94-1
• UNSPSC Description: 5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-o-dmt-2-thio-2-du-3-phosphoramidite.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
• Molecular Weight: 746.85
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported