Rosomidnar

CAT: 0804-HY-153494Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-153494Size:1 Each

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Description

PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

CAS Number

871597-03-4

Product Name Alternative

PNT100

UNSPSC

12352208

Target

Bcl-2 Family

Type

Oligonucleotides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rosomidnar.html

Solubility

10 mM in H2O

Smiles

[Rosomidnar]

Molecular Formula

C227H291N88O141P23

Molecular Weight

7220.63

References & Citations

[1]Rodrigueza WV, Woolliscroft MJ, Ebrahim AS, et al. Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemother Pharmacol. 2014;74 (1) :151-166.|[2]Westin J, Maris MB, Jacobson CA, et al. Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022;22 (1) :52-59.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

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