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Cimdelirsen

CAT: 0804-HY-153485Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153485Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
CAS Number
2131025-82-4
Product Name Alternative
ISIS 766720; IONIS-GHR-LRx
UNSPSC
12352208
Target
GHR; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cimdelirsen.html
Solubility
10 mM in H2O
Smiles
[Cimdelirsen]
Molecular Formula
C296H435N83O152P20S15
Molecular Weight
8688.52
References & Citations
[1]Bhanot S, Fleseriu M, Geary R, et al. OR27-4 Placebo-Controlled and Open-Label Extension Study of a Novel Hepatic-Targeted Antisense Cimdelirsen (IONIS-GHR-LRx) Under Investigation in Acromegaly Patients. J Endocr Soc. 2022;6 (Suppl 1) :A526.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 2

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