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ARC19499

CAT: 0804-HY-153480Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153480Size:1 Each
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Description
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI), thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
CAS Number
1350667-54-7
Product Name Alternative
BAX499
UNSPSC
12352208
Target
Factor VIIa; Factor Xa; Tissue Factor Pathway Inhibitor (TFPI)
Type
Oligonucleotides
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/arc19499.html
Purity
93.65
Solubility
H2O : ≥ 100 mg/mL
Smiles
[ARC19499]
Molecular Weight
11078.95
References & Citations
[1]Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood. 2011;117 (20) :5514-5522.|[2]Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia. Thromb Res. 2012;130 (6) :948-955.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 1

Alternative Products

CatalogName
T75152-01ARC19499

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