Fmoc-DON-Boc

• Description :

  Fmoc-DON-Boc (Compound 8b) is an Fmoc-protected compound that can be used for the synthesis of proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357) . DON is a glutamine antagonist[1].

• UNSPSC :

  12352005

• Target :

  Drug Intermediate

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fmoc-don-boc.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)OC([C@H](CCC(C=[N+]=[N-])=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

• Molecular Formula :

  C24H25N3O5

• Molecular Weight :

  435.47

• References & Citations :

  [1]Rais R, et al. Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma. J Med Chem. 2016 Sep 22;59 (18) :8621-33.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1998724-98-3]