6-Methoxypurine-9-β-D-5’(R)-C-methylriboside

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside

• UNSPSC Description: 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/6-methoxypurine-9-β-d-5-r-c-methylriboside.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@]([H])(C)[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CN=C3OC)=C3N=C2)O1
• Molecular Weight: 296.28
• References & Citations: [1]Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.|[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported