3’-Azido-3’-deoxy-5-methyl-beta-L-uridine

3’-Azido-3’-deoxy-5-methyl-beta-L-uridine

• CAS Number: 2095417-10-8
• UNSPSC Description: 3’-Azido-3’-deoxy-5-methyl-beta-L-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-5-methyl-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/3-azido-3-deoxy-5-methyl-beta-l-uridine.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1[C@@H](N=[N+]=[N-])[C@H](CO)O[C@@H]1N2C=C(C)C(NC2=O)=O
• Molecular Weight: 283.24
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported