Clathrin-IN-2

• UNSPSC Description:

  Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1].

• Target Antigen:

  Dynamin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/clathrin-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(C[C@@H](CN1C2=CC=C(C=C2C3=CC(Br)=CC=C31)Br)O)C

• Molecular Weight:

  426.15

• References & Citations:

  [1]Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2650733-69-8