KY216

CAT: 0804-HY-152143Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-152143Size:1 Each

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Description

KY216 (Tubulin polymerization-IN-41) is a potent tubulin polymerization inhibitor with the IC50 of 2.61 μM. KY216 targets the Colchicine-binding site of tubulin. KY216 can be used for the study of non-small cell lung cancer (NSCLC) and breast cancer[1][2].

CAS Number

2804026-81-9

Product Name Alternative

Tubulin polymerization-IN-41

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-41.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@H](C2=CC3=C(C=C2C[C@H]14)OCCO3)C5=CC(Cl)=C(C(Cl)=C5)OC)NC4=O

Molecular Formula

C20H16Cl2N2O5

Molecular Weight

435.26

References & Citations

[1]Jiafu Leng, et al. Discovery of Novel N-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment. J Med Chem. 2022 Dec 22;65 (24) :16774-16800. |[2]He XY, et al. KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis. Nat Commun. 2025 Dec 4.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

KY216

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