(R,R)-LRRK2-IN-7

(R,R)-LRRK2-IN-7

• CAS Number: 2307277-92-3
• UNSPSC Description: (R,R)-LRRK2-IN-7 is the isomer of LRRK2-IN-7 (HY-152107). LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes.
• Target Antigen: LRRK2
• Type: Reference compound
• Related Pathways: Autophagy
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/r-r-lrrk2-in-7.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)(O)[C@@H]1CCN(C1)C2=NC=NC(N3C4=CC([C@]5(CC56CC6)C#N)=CC=C4C=N3)=C2
• Molecular Weight: 414.50
• References & Citations: [1]David A Candito, et al. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J Med Chem. 2022 Dec 22;65(24):16801-16817.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported