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DIBA-Cy5

CAT: 0804-HY-151801Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151801Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the Kd value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart[1].
UNSPSC
12171500
Target
MAChR
Type
Dye Reagents
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/diba-cy5.html
Solubility
10 mM in DMSO
Smiles
CC1(C2=CC(S(=O)([O-])=O)=CC=C2[N+](CCCCCC(NCCCN3C=C(N=N3)CCN4CCN(CC4)CCCCC5CCN(CC5)CC(N6C7=CC=CC=C7NC(C8=C6C=CC=C8)=O)=O)=O)=C1/C=C/C=C/C=C9N(C%10=C(C/9(C)C)C=C(C=C%10)S(=O)(O)=O)CCCS(=O)(O)=O)C
Molecular Formula
C69H89N11O12S3
Molecular Weight
1360.71
References & Citations
[1]Yang H, et al. Click Chemistry-Enabled Conjugation Strategy for Producing Dibenzodiazepinone-Type Fluorescent Probes To Target M2 Acetylcholine Receptors. Bioconjug Chem. 2022 Nov 3.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2